Lep/Cer (d18:1/25:0) ratio differentiated PE from normal pregnancies
The Lep/Cer (d18:1/25:0) ratio had the largest area under the curve (AUC) compared with other marker combinations (Fig. 4B and Appendix 4) for differentiating PE from non-PE women in the testing cohort. Furthermore, compared with the individual Lep and Cer (d18:1/25:0) levels, the Lep/Cer (d18:1/25:0) ratio showed a lower P (0.006 vs 0.02 and 0.03, respectively), a larger fold change (4.04 vs 2.97 and 0.88, respectively), and a higher AUC (0.911 vs 0.875 and 0.839, respectively; Table III and Appendix 5).